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Mendeliome

Gene: KRAS

Green List (high evidence)

KRAS (KRAS proto-oncogene, GTPase)
EnsemblGeneIds (GRCh38): ENSG00000133703
EnsemblGeneIds (GRCh37): ENSG00000133703
OMIM: 190070, Gene2Phenotype
KRAS is in 21 panels

1 review

Elena Savva (Victorian Clinical Genetics Services)

Green List (high evidence)

GoF is the only one reported
* Several missenses have moderate GoF
* It was suggested that somatic or germline GoF could have different mechanisms
Created: 22 May 2020, 5:52 a.m. | Last Modified: 22 May 2020, 5:52 a.m.
Panel Version: 0.2861

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Phenotypes
Arteriovenous malformation of the brain, somatic 108010; Bladder cancer, somatic 109800; Breast cancer, somatic 114480; Cardiofaciocutaneous syndrome 2 615278; Gastric cancer, somatic 137215; Leukemia, acute myeloid 601626; . Lung cancer, somatic 211980; Noonan syndrome 3 609942; Pancreatic carcinoma, somatic 260350; RAS-associated autoimmune leukoproliferative disorder 614470; Schimmelpenning-Feuerstein-Mims syndrome, somatic mosaic 163200

Publications

Mode of pathogenicity
Other

Variants in this GENE are reported as part of current diagnostic practice

Details

Mode of Inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Sources
  • Expert Review Green
  • Victorian Clinical Genetics Services
Phenotypes
  • Cardiofaciocutaneous syndrome 2 615278
  • Noonan syndrome 3 609942
  • RAS-associated autoimmune leukoproliferative disorder 614470
  • Schimmelpenning-Feuerstein-Mims syndrome, somatic mosaic 163200
OMIM
190070
Clinvar variants
Variants in KRAS
Penetrance
None
Publications
Mode of Pathogenicity
Other
Panels with this gene

History Filter Activity

22 May 2020, Gel status: 3

Entity classified by Genomics England curator

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Gene: kras has been classified as Green List (High Evidence).

22 May 2020, Gel status: 3

Set Phenotypes

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Phenotypes for gene: KRAS were changed from to Cardiofaciocutaneous syndrome 2 615278; Noonan syndrome 3 609942; RAS-associated autoimmune leukoproliferative disorder 614470; Schimmelpenning-Feuerstein-Mims syndrome, somatic mosaic 163200

22 May 2020, Gel status: 3

Set publications

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Publications for gene: KRAS were set to

22 May 2020, Gel status: 3

Set mode of pathogenicity

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Mode of pathogenicity for gene: KRAS was changed from to Other

22 May 2020, Gel status: 3

Set mode of inheritance

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Mode of inheritance for gene: KRAS was changed from Unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

17 Nov 2019, Gel status: 3

Created, Added New Source, Set mode of inheritance

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

gene: KRAS was added gene: KRAS was added to Mendeliome_VCGS. Sources: Expert Review Green,Victorian Clinical Genetics Services Mode of inheritance for gene: KRAS was set to Unknown