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Mendeliome

Gene: HCRT

Red List (low evidence)

HCRT (hypocretin neuropeptide precursor)
EnsemblGeneIds (GRCh38): ENSG00000161610
EnsemblGeneIds (GRCh37): ENSG00000161610
OMIM: 602358, Gene2Phenotype
HCRT is in 1 panel

1 review

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Red List (low evidence)

Single report of a novel missense in an individual with narcolepsy, not inherited from one parent, the other parent unavailable for testing.

Other variants reported are referred to as polymorphisms.
Created: 2 May 2022, 1:43 a.m. | Last Modified: 2 May 2022, 1:43 a.m.
Panel Version: 0.13577

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Phenotypes
Narcolepsy 1 , MIM# 161400

Publications

Details

Mode of Inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Sources
  • Expert Review Red
  • Victorian Clinical Genetics Services
Phenotypes
  • Narcolepsy 1 , MIM# 161400
OMIM
602358
Clinvar variants
Variants in HCRT
Penetrance
None
Publications
Panels with this gene

History Filter Activity

2 May 2022, Gel status: 1

Entity classified by Genomics England curator

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Gene: hcrt has been classified as Red List (Low Evidence).

2 May 2022, Gel status: 1

Set Phenotypes

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Phenotypes for gene: HCRT were changed from to Narcolepsy 1 , MIM# 161400

2 May 2022, Gel status: 1

Set publications

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Publications for gene: HCRT were set to

2 May 2022, Gel status: 1

Set mode of inheritance

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Mode of inheritance for gene: HCRT was changed from Unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

2 May 2022, Gel status: 1

Entity classified by Genomics England curator

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Gene: hcrt has been classified as Red List (Low Evidence).

17 Nov 2019, Gel status: 3

Created, Added New Source, Set mode of inheritance

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

gene: HCRT was added gene: HCRT was added to Mendeliome_VCGS. Sources: Expert Review Green,Victorian Clinical Genetics Services Mode of inheritance for gene: HCRT was set to Unknown