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Mendeliome

Gene: CYP2D6

Red List (low evidence)

CYP2D6 (cytochrome P450 family 2 subfamily D member 6)
EnsemblGeneIds (GRCh38): ENSG00000100197
EnsemblGeneIds (GRCh37): ENSG00000100197
OMIM: 124030, Gene2Phenotype
CYP2D6 is in 2 panels

1 review

Ain Roesley (Victorian Clinical Genetics Services)

Red List (low evidence)

Pharmacogenomics gene

Codeine, tramadol, oxycodone
Created: 8 May 2022, 10:19 p.m. | Last Modified: 8 May 2022, 10:19 p.m.
Panel Version: 0.13920

Phenotypes
{Codeine sensitivity} MIM#608902; {Debrisoquine sensitivity} MIM#608902

Publications

Variants in this GENE are reported as part of current diagnostic practice

Details

Mode of Inheritance
Unknown
Sources
  • Expert Review Red
  • Victorian Clinical Genetics Services
Phenotypes
  • {Codeine sensitivity} MIM#608902
  • {Debrisoquine sensitivity} MIM#608902
OMIM
124030
Clinvar variants
Variants in CYP2D6
Penetrance
None
Publications
Panels with this gene

History Filter Activity

8 May 2022, Gel status: 1

Entity classified by Genomics England curator

Ain Roesley (Victorian Clinical Genetics Services)

Gene: cyp2d6 has been classified as Red List (Low Evidence).

8 May 2022, Gel status: 1

Set Phenotypes

Ain Roesley (Victorian Clinical Genetics Services)

Phenotypes for gene: CYP2D6 were changed from to {Codeine sensitivity} MIM#608902; {Debrisoquine sensitivity} MIM#608902

8 May 2022, Gel status: 1

Set publications

Ain Roesley (Victorian Clinical Genetics Services)

Publications for gene: CYP2D6 were set to

8 May 2022, Gel status: 1

Entity classified by Genomics England curator

Ain Roesley (Victorian Clinical Genetics Services)

Gene: cyp2d6 has been classified as Red List (Low Evidence).

17 Nov 2019, Gel status: 3

Created, Added New Source, Set mode of inheritance

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

gene: CYP2D6 was added gene: CYP2D6 was added to Mendeliome_VCGS. Sources: Expert Review Green,Victorian Clinical Genetics Services Mode of inheritance for gene: CYP2D6 was set to Unknown