Entity Name	Entity type	Gene Symbol	Sources(; separated)	Level4	Level3	Level2	Model_Of_Inheritance	Phenotypes	Omim	Orphanet	HPO	Publications	Description	Flagged	GEL_Status	UserRatings_Green_amber_red	version	ready	Mode of pathogenicity	EnsemblId(GRch37)	EnsemblId(GRch38)	HGNC	Position Chromosome	Position GRCh37 Start	Position GRCh37 End	Position GRCh38 Start	Position GRCh38 End	STR Repeated Sequence	STR Normal Repeats	STR Pathogenic Repeats	Region Haploinsufficiency Score	Region Triplosensitivity Score	Region Required Overlap Percentage	Region Variant Type	Region Verbose Name
ADAMTS3	gene	ADAMTS3	Expert Review;Expert Review Green	Lymphoedema_nonsyndromic		Cardiovascular disorders	BIALLELIC, autosomal or pseudoautosomal	Hennekam lymphangiectasia-lymphedema syndrome 3 (618154)			Lymphedema;HP:0001004	28985353, 30450763		False	3	100;0;0	0.44	True		ENSG00000156140	ENSG00000156140	HGNC:219													
ANGPT2	gene	ANGPT2	Expert Review Green;Literature	Lymphoedema_nonsyndromic		Cardiovascular disorders	BOTH monoallelic and biallelic (but BIALLELIC mutations cause a more SEVERE disease form), autosomal or pseudoautosomal	Lymphatic malformation-10, MIM#619369;Primary lymphoedema;Hydrops			Lymphedema;HP:0001004	32908006;34876502		False	3	100;0;0	0.44	True		ENSG00000091879	ENSG00000091879	HGNC:485													
CCBE1	gene	CCBE1	Expert Review Green;Victorian Clinical Genetics Services	Lymphoedema_nonsyndromic		Cardiovascular disorders	Unknown				Lymphedema;HP:0001004			False	3	0;0;0	0.44	False		ENSG00000183287	ENSG00000183287	HGNC:29426													
CELSR1	gene	CELSR1	Expert Review Green;Literature	Lymphoedema_nonsyndromic		Cardiovascular disorders	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Lymphatic malformation 9, MIM# 619319			Lymphedema;HP:0001004	31215153;31403174;26855770		False	3	100;0;0	0.44	True		ENSG00000075275	ENSG00000075275	HGNC:1850													
EPHB4	gene	EPHB4	Expert Review Green;Victorian Clinical Genetics Services	Lymphoedema_nonsyndromic		Cardiovascular disorders	Unknown				Lymphedema;HP:0001004			False	3	0;0;0	0.44	False		ENSG00000196411	ENSG00000196411	HGNC:3395													
ERG	gene	ERG	Expert Review Green;Literature	Lymphoedema_nonsyndromic		Cardiovascular disorders	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	"Lymphatic malformation 14, MIM#	620602"			Lymphedema;HP:0001004	36928819		False	3	100;0;0	0.44	True		ENSG00000157554	ENSG00000157554	HGNC:3446													
FAT4	gene	FAT4	Expert Review Green;Victorian Clinical Genetics Services	Lymphoedema_nonsyndromic		Cardiovascular disorders	Unknown				Lymphedema;HP:0001004			False	3	0;0;0	0.44	False		ENSG00000196159	ENSG00000196159	HGNC:23109													
FLT4	gene	FLT4	Expert Review Green;Victorian Clinical Genetics Services	Lymphoedema_nonsyndromic		Cardiovascular disorders	Unknown				Lymphedema;HP:0001004			False	3	0;0;0	0.44	False		ENSG00000037280	ENSG00000037280	HGNC:3767													
FOXC2	gene	FOXC2	Expert Review Green;Victorian Clinical Genetics Services	Lymphoedema_nonsyndromic		Cardiovascular disorders	Unknown				Lymphedema;HP:0001004			False	3	0;0;0	0.44	False		ENSG00000176692	ENSG00000176692	HGNC:3801													
GATA2	gene	GATA2	Expert Review Green;Victorian Clinical Genetics Services	Lymphoedema_nonsyndromic		Cardiovascular disorders	Unknown				Lymphedema;HP:0001004			False	3	0;0;0	0.44	False		ENSG00000179348	ENSG00000179348	HGNC:4171													
GJA1	gene	GJA1	Expert Review Green;Victorian Clinical Genetics Services	Lymphoedema_nonsyndromic		Cardiovascular disorders	Unknown				Lymphedema;HP:0001004			False	3	0;0;0	0.44	False		ENSG00000152661	ENSG00000152661	HGNC:4274													
GJC2	gene	GJC2	Expert Review Green;Victorian Clinical Genetics Services	Lymphoedema_nonsyndromic		Cardiovascular disorders	Unknown				Lymphedema;HP:0001004			False	3	0;0;0	0.44	False		ENSG00000198835	ENSG00000198835	HGNC:17494													
HGF	gene	HGF	Expert Review Green;Literature	Lymphoedema_nonsyndromic		Cardiovascular disorders	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Lymphoedema, MONDO:0019297, HGF-related			Lymphedema;HP:0001004	38676400;38791500		False	3	100;0;0	0.44	True		ENSG00000019991	ENSG00000019991	HGNC:4893													
IKBKG	gene	IKBKG	Expert Review Green;Victorian Clinical Genetics Services	Lymphoedema_nonsyndromic		Cardiovascular disorders	Unknown				Lymphedema;HP:0001004			False	3	0;0;0	0.44	False		ENSG00000073009	ENSG00000269335	HGNC:5961													
MDFIC	gene	MDFIC	Expert Review Green;Literature	Lymphoedema_nonsyndromic		Cardiovascular disorders	BIALLELIC, autosomal or pseudoautosomal	Lymphatic malformation 12 - MIM#620014			Lymphedema;HP:0001004	PMID: 35235341		False	3	100;0;0	0.44	True		ENSG00000135272	ENSG00000135272	HGNC:28870													
PIEZO1	gene	PIEZO1	Expert Review Green;Victorian Clinical Genetics Services	Lymphoedema_nonsyndromic		Cardiovascular disorders	Unknown				Lymphedema;HP:0001004			False	3	0;0;0	0.44	False		ENSG00000103335	ENSG00000103335	HGNC:28993													
PTPN14	gene	PTPN14	Expert list;Expert Review Green	Lymphoedema_nonsyndromic		Cardiovascular disorders	BIALLELIC, autosomal or pseudoautosomal	"Choanal atresia and lymphedema	MIM#613611"			Lymphedema;HP:0001004	20826270;https://doi.org/10.1016/j.mgene.2017.07.006		False	3	100;0;0	0.44	True		ENSG00000152104	ENSG00000152104	HGNC:9647													
SOX18	gene	SOX18	Expert Review Green;Victorian Clinical Genetics Services	Lymphoedema_nonsyndromic		Cardiovascular disorders	Unknown				Lymphedema;HP:0001004			False	3	0;0;0	0.44	False		ENSG00000203883	ENSG00000203883	HGNC:11194													
TIE1	gene	TIE1	Expert Review Green;Literature	Lymphoedema_nonsyndromic		Cardiovascular disorders	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	"Lymphatic malformation 11, MIM#	619401"			Lymphedema;HP:0001004	32947856;24764452;38820174		False	3	50;50;0	0.44	True		ENSG00000066056	ENSG00000066056	HGNC:11809													
VEGFC	gene	VEGFC	Expert Review Green;Victorian Clinical Genetics Services	Lymphoedema_nonsyndromic		Cardiovascular disorders	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Lymphatic malformation 4, MIM#615907			Lymphedema;HP:0001004	23410910;24744435;30071673		False	3	100;0;0	0.44	True		ENSG00000150630	ENSG00000150630	HGNC:12682													
ARAP3	gene	ARAP3	Expert Review Amber;Literature	Lymphoedema_nonsyndromic		Cardiovascular disorders	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Lymphoedema, MONDO:0019297, ARAP3-related			Lymphedema;HP:0001004	32908855		False	2	0;100;0	0.44	True		ENSG00000120318	ENSG00000120318	HGNC:24097													
KIF11	gene	KIF11	Expert Review Amber;Victorian Clinical Genetics Services	Lymphoedema_nonsyndromic		Cardiovascular disorders	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Microcephaly with or without chorioretinopathy, lymphoedema, or mental retardation, MIM# 152950;MONDO:0007918			Lymphedema;HP:0001004	22284827;25115524;25124931;27212378;32730767;31993640;25996076		False	2	0;100;0	0.44	True		ENSG00000138160	ENSG00000138160	HGNC:6388													
RORC	gene	RORC	Expert Review Amber;Literature	Lymphoedema_nonsyndromic		Cardiovascular disorders	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Lymphoedema			Lymphedema;HP:0001004	32960152		False	2	0;100;0	0.44	True		ENSG00000143365	ENSG00000143365	HGNC:10260