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  3. TRIM28
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Incidentalome

Gene: TRIM28

Green List (high evidence)
TRIM28 (tripartite motif containing 28)
EnsemblGeneIds (GRCh38): ENSG00000130726
EnsemblGeneIds (GRCh37): ENSG00000130726
OMIM: 601742, Gene2Phenotype
TRIM28 is in 4 panels

1 review

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Green List (high evidence)

Eleven individuals with germline variants identified; plus one somatic. Exome sequencing on eight tumor DNA samples from six individuals showed loss-of-heterozygosity (LOH) of the TRIM28-locus by mitotic recombination in seven tumors, suggesting that TRIM28 functions as a tumor suppressor gene in Wilms tumor development.
Sources: Literature
Created: 6 Jan 2020, 4:20 a.m.

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Phenotypes
Wilm's tumour

Publications

Created: 6 Jan 2020, 4:20 a.m.

Panel version: 0.3

Details

Mode of Inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Sources
  • Expert Review Green
  • Literature
Phenotypes
  • Wilm's tumour
OMIM
601742
Clinvar variants
Variants in TRIM28
Penetrance
None
Publications
Panels with this gene

History Filter Activity

6 Jan 2020, Gel status: 3

Entity classified by Genomics England curator

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Gene: trim28 has been classified as Green List (High Evidence).

6 Jan 2020, Gel status: 3

Entity classified by Genomics England curator

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Gene: trim28 has been classified as Green List (High Evidence).

6 Jan 2020, Gel status: 1

Created, Added New Source, Set mode of inheritance, Set publications, Set Phenotypes

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

gene: TRIM28 was added gene: TRIM28 was added to Incidentalome_VCGS. Sources: Literature Mode of inheritance for gene: TRIM28 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted Publications for gene: TRIM28 were set to 30694527 Phenotypes for gene: TRIM28 were set to Wilm's tumour Review for gene: TRIM28 was set to GREEN