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  3. SCN4B
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Incidentalome

Gene: SCN4B

Red List (low evidence)
SCN4B (sodium voltage-gated channel beta subunit 4)
EnsemblGeneIds (GRCh38): ENSG00000177098
EnsemblGeneIds (GRCh37): ENSG00000177098
OMIM: 608256, Gene2Phenotype
SCN4B is in 4 panels

1 review

Ivan Macciocca (Victorian Clinical Genetics Services)

Red List (low evidence)

disputed as reported in Circulation. 2020 Feb 11;141(6):418-428 PMID: 31983240, by the International, Multicentered LQTS ClinGen Working Group
Created: 31 May 2020, 2:11 p.m. | Last Modified: 31 May 2020, 2:11 p.m.
Panel Version: 0.7

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Phenotypes
long QT syndrome

Publications

Created: 31 May 2020, 2:11 p.m.
Last Modified: 31 May 2020, 2:11 p.m.
Panel version: Imported from Long QT Syndrome panel version 0.7

Details

Mode of Inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Sources
  • Expert Review Red
  • Victorian Clinical Genetics Services
Phenotypes
  • Long QT syndrome 10, MIM# 611819
Tags
disputed cardiac
OMIM
608256
Clinvar variants
Variants in SCN4B
Penetrance
None
Publications
Panels with this gene

History Filter Activity

12 Aug 2022, Gel status: 1

Added Tag

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Tag disputed tag was added to gene: SCN4B.

12 Aug 2022, Gel status: 1

Entity classified by Genomics England curator

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Gene: scn4b has been classified as Red List (Low Evidence).

12 Aug 2022, Gel status: 1

Set Phenotypes

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Phenotypes for gene: SCN4B were changed from to Long QT syndrome 10, MIM# 611819

12 Aug 2022, Gel status: 1

Set publications

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Publications for gene: SCN4B were set to

12 Aug 2022, Gel status: 1

Set mode of inheritance

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Mode of inheritance for gene: SCN4B was changed from Unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

12 Aug 2022, Gel status: 1

Entity classified by Genomics England curator

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Gene: scn4b has been classified as Red List (Low Evidence).

12 Aug 2022, Gel status: 3

Added Tag

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Tag cardiac tag was added to gene: SCN4B.

17 Nov 2019, Gel status: 3

Created, Added New Source, Set mode of inheritance

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

gene: SCN4B was added gene: SCN4B was added to Incidentalome_VCGS. Sources: Expert Review Green,Victorian Clinical Genetics Services Mode of inheritance for gene: SCN4B was set to Unknown