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  3. NR4A2
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Incidentalome

Gene: NR4A2

Red List (low evidence)
NR4A2 (nuclear receptor subfamily 4 group A member 2)
EnsemblGeneIds (GRCh38): ENSG00000153234
EnsemblGeneIds (GRCh37): ENSG00000153234
OMIM: 601828, Gene2Phenotype
NR4A2 is in 7 panels

2 reviews

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Red List (low evidence)

Disputed link of polymorphisms in this gene with susceptibility to Parkinson's disease. Gene has now been associated with ID in multiple families. Move to Mendeliome.
Created: 10 May 2020, 2:55 a.m. | Last Modified: 10 May 2020, 2:55 a.m.
Panel Version: 0.19

Publications

Created: 10 May 2020, 2:55 a.m.
Last Modified: 10 May 2020, 2:55 a.m.
Panel version: 0.19

Bryony Thompson (Royal Melbourne Hospital)

Red List (low evidence)

Dopamine neuron agenesis occurs in Nurr1 deficient mice. No evidence that rare variants in this gene cause dementia. Was initially reported as a Parkinson disease susceptibility loci, but has not been replicated in large studies.
Created: 6 Feb 2020, 5:27 a.m. | Last Modified: 6 Feb 2020, 5:27 a.m.
Panel Version: 0.6

Mode of inheritance
Unknown

Publications

Created: 6 Feb 2020, 5:27 a.m.
Last Modified: 6 Feb 2020, 5:27 a.m.
Panel version: Imported from Early-onset Dementia panel version 0.6

Details

Mode of Inheritance
Unknown
Sources
  • Expert Review Red
  • Expert Review Red
  • Victorian Clinical Genetics Services
OMIM
601828
Clinvar variants
Variants in NR4A2
Penetrance
None
Panels with this gene

History Filter Activity

10 May 2020, Gel status: 1

Entity classified by Genomics England curator

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Gene: nr4a2 has been classified as Red List (Low Evidence).

10 May 2020, Gel status: 1

Entity classified by Genomics England curator

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Gene: nr4a2 has been classified as Red List (Low Evidence).

17 Nov 2019, Gel status: 3

Created, Added New Source, Set mode of inheritance

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

gene: NR4A2 was added gene: NR4A2 was added to Incidentalome_VCGS. Sources: Expert Review Green,Victorian Clinical Genetics Services Mode of inheritance for gene: NR4A2 was set to Unknown