Incidentalome
Gene: KCNE2
Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Phenotypes
Long QT syndrome 6, MIM# 613693
Publications
as reported in Circulation. 2020 Feb 11;141(6):418-428 PMID: 31983240, by the International, Multicentered LQTS ClinGen Working Group:
KCNE2 was concluded to have strong evidence for acquired LQTS, however a recent comprehensive review of reported KCNE2 variants reported for LQTS demonstrated that KCNE2 variants routinely require secondary provocation to induce
phenotype, persuading the Working Group to conclude that KCNE2 has no supportive evidence as a cause of
LQTS in the absence of provoking factors (PMID: 28794082).Created: 31 May 2020, 1:55 p.m. | Last Modified: 31 May 2020, 1:55 p.m.
Panel Version: 0.7
Publications
Variants in this GENE are reported as part of current diagnostic practice
Gene: kcne2 has been classified as Amber List (Moderate Evidence).
Phenotypes for gene: KCNE2 were changed from to Long QT syndrome 6, MIM# 613693
Publications for gene: KCNE2 were set to
Mode of inheritance for gene: KCNE2 was changed from Unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Gene: kcne2 has been classified as Amber List (Moderate Evidence).
Tag cardiac tag was added to gene: KCNE2.
gene: KCNE2 was added gene: KCNE2 was added to Incidentalome_VCGS. Sources: Expert Review Green,Victorian Clinical Genetics Services Mode of inheritance for gene: KCNE2 was set to Unknown