1. Panels
  2. Incidentalome
  3. CLU
STRs in panel
Prev Next
Regions in panel
Prev Next

Incidentalome

Gene: CLU

Red List (low evidence)
CLU (clusterin)
EnsemblGeneIds (GRCh38): ENSG00000120885
EnsemblGeneIds (GRCh37): ENSG00000120885
OMIM: 185430, Gene2Phenotype
CLU is in 1 panel

1 review

Sangavi Sivagnanasundram (Melbourne Health)

Red List (low evidence)

Gene Reviews NBK1161/PMID: 20301340 state that variants in CLU are known to cause AD however there is no known clinical utility

PMID: 19734903 – GWAS study that identifies SNPs in CLU are associated with Alzheimer’s disease
Created: 29 Mar 2023, 2:43 a.m. | Last Modified: 29 Mar 2023, 2:43 a.m.
Panel Version: 0.223

Mode of inheritance
Unknown

Phenotypes
Alzheimer's Disease (MIM#104300)

Publications

Mode of pathogenicity
Other

Created: 29 Mar 2023, 2:43 a.m.
Last Modified: 29 Mar 2023, 2:43 a.m.
Panel version: 0.223

Details

Mode of Inheritance
Unknown
Sources
  • Expert Review Red
  • Victorian Clinical Genetics Services
Phenotypes
  • Alzheimer's Disease (MIM#104300)
OMIM
185430
Clinvar variants
Variants in CLU
Penetrance
None
Panels with this gene

History Filter Activity

21 Aug 2023, Gel status: 1

Entity classified by Genomics England curator

Bryony Thompson (Royal Melbourne Hospital)

Gene: clu has been classified as Red List (Low Evidence).

21 Aug 2023, Gel status: 1

Set Phenotypes

Bryony Thompson (Royal Melbourne Hospital)

Phenotypes for gene: CLU were changed from to Alzheimer's Disease (MIM#104300)

21 Aug 2023, Gel status: 1

Entity classified by Genomics England curator

Bryony Thompson (Royal Melbourne Hospital)

Gene: clu has been classified as Red List (Low Evidence).

17 Nov 2019, Gel status: 3

Created, Added New Source, Set mode of inheritance

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

gene: CLU was added gene: CLU was added to Incidentalome_VCGS. Sources: Expert Review Green,Victorian Clinical Genetics Services Mode of inheritance for gene: CLU was set to Unknown