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  3. CCNF
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Incidentalome

Gene: CCNF

Amber List (moderate evidence)
CCNF (cyclin F)
EnsemblGeneIds (GRCh38): ENSG00000162063
EnsemblGeneIds (GRCh37): ENSG00000162063
OMIM: 600227, Gene2Phenotype
CCNF is in 3 panels

2 reviews

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

I don't know

LIMITED by ClinGen
Created: 22 Nov 2023, 12:58 a.m. | Last Modified: 22 Nov 2023, 12:58 a.m.
Panel Version: 0.295

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Phenotypes
Frontotemporal dementia and/or amyotrophic lateral sclerosis 5, MIM# 619141

Created: 16 Jan 2021, 12:23 a.m.
Last Modified: 16 Jan 2021, 12:23 a.m.
Panel version: 0.295

Bryony Thompson (Royal Melbourne Hospital)

Green List (high evidence)

Comment on list classification: Limited gene-disease validity assessment by ClinGen ALS spectrum disorders GCEP - 05/04/2022
Created: 21 Aug 2023, 11:25 p.m. | Last Modified: 21 Aug 2023, 11:25 p.m.
Panel Version: 0.261
>3 families/cases and supporting functional evidence
Sources: Expert list
Created: 28 Mar 2020, 6:16 a.m.

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Phenotypes
amyotrophic lateral sclerosis with/without frontotemporal dementia

Publications

Created: 28 Mar 2020, 6:16 a.m.

Panel version: 0.15

Details

Mode of Inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Sources
  • Expert Review Amber
  • Expert list
Phenotypes
  • Frontotemporal dementia and/or amyotrophic lateral sclerosis 5, MIM# 619141
OMIM
600227
Clinvar variants
Variants in CCNF
Penetrance
None
Publications
Panels with this gene

History Filter Activity

21 Aug 2023, Gel status: 2

Entity classified by Genomics England curator

Bryony Thompson (Royal Melbourne Hospital)

Gene: ccnf has been classified as Amber List (Moderate Evidence).

21 Aug 2023, Gel status: 2

Entity classified by Genomics England curator

Bryony Thompson (Royal Melbourne Hospital)

Gene: ccnf has been classified as Amber List (Moderate Evidence).

16 Jan 2021, Gel status: 3

Entity classified by Genomics England curator

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Gene: ccnf has been classified as Green List (High Evidence).

16 Jan 2021, Gel status: 3

Set Phenotypes

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Phenotypes for gene: CCNF were changed from amyotrophic lateral sclerosis with/without frontotemporal dementia to Frontotemporal dementia and/or amyotrophic lateral sclerosis 5, MIM# 619141

28 Mar 2020, Gel status: 3

Entity classified by Genomics England curator

Bryony Thompson (Royal Melbourne Hospital)

Gene: ccnf has been classified as Green List (High Evidence).

28 Mar 2020, Gel status: 1

Created, Added New Source, Set mode of inheritance, Set publications, Set Phenotypes

Bryony Thompson (Royal Melbourne Hospital)

gene: CCNF was added gene: CCNF was added to Incidentalome. Sources: Expert list Mode of inheritance for gene: CCNF was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted Publications for gene: CCNF were set to 27080313; 31577344 Phenotypes for gene: CCNF were set to amyotrophic lateral sclerosis with/without frontotemporal dementia Review for gene: CCNF was set to GREEN