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  3. A2M
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Incidentalome

Gene: A2M

Amber List (moderate evidence)
A2M (alpha-2-macroglobulin)
EnsemblGeneIds (GRCh38): ENSG00000175899
EnsemblGeneIds (GRCh37): ENSG00000175899
OMIM: 103950, Gene2Phenotype
A2M is in 1 panel

1 review

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Red List (low evidence)

Polymorphisms in this gene have been linked to Alzheimer's disease but this is not a Mendelian gene-disease association.
Created: 12 Aug 2022, 5:34 a.m. | Last Modified: 12 Aug 2022, 5:34 a.m.
Panel Version: 0.210

Phenotypes
Alzheimer disease, MONDO:0004975

Created: 12 Aug 2022, 5:34 a.m.
Last Modified: 12 Aug 2022, 5:34 a.m.
Panel version: 0.210

Details

Mode of Inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Sources
  • Expert Review Amber
  • Victorian Clinical Genetics Services
Phenotypes
  • Alzheimer disease, MONDO:0004975
Tags
adult onset neurodegenerative
OMIM
103950
Clinvar variants
Variants in A2M
Penetrance
None
Panels with this gene

History Filter Activity

27 Feb 2025, Gel status: 2

Entity classified by Genomics England curator

(Other)

Gene: a2m has been classified as Amber List (Moderate Evidence).

27 Feb 2025, Gel status: 3

Entity classified by Genomics England curator

(Other)

Gene: a2m has been classified as Green List (High Evidence).

27 Feb 2025, Gel status: 2

Entity classified by Genomics England curator

Katrina Bell (Murdoch Children's Research Institute)

Gene: a2m has been classified as Amber List (Moderate Evidence).

27 Feb 2025, Gel status: 2

Entity classified by Genomics England curator

Katrina Bell (Murdoch Children's Research Institute)

Gene: a2m has been classified as Amber List (Moderate Evidence).

27 Feb 2025, Gel status: 2

Entity classified by Genomics England curator

Katrina Bell (Murdoch Children's Research Institute)

Gene: a2m has been classified as Amber List (Moderate Evidence).

12 Aug 2022, Gel status: 1

Entity classified by Genomics England curator

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Gene: a2m has been classified as Red List (Low Evidence).

12 Aug 2022, Gel status: 1

Set Phenotypes

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Phenotypes for gene: A2M were changed from to Alzheimer disease, MONDO:0004975

12 Aug 2022, Gel status: 1

Set mode of inheritance

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Mode of inheritance for gene: A2M was changed from Unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

12 Aug 2022, Gel status: 1

Entity classified by Genomics England curator

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Gene: a2m has been classified as Red List (Low Evidence).

12 Aug 2022, Gel status: 3

Added Tag

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Tag adult onset neurodegenerative tag was added to gene: A2M.

17 Nov 2019, Gel status: 3

Created, Added New Source, Set mode of inheritance

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

gene: A2M was added gene: A2M was added to Incidentalome_VCGS. Sources: Expert Review Green,Victorian Clinical Genetics Services Mode of inheritance for gene: A2M was set to Unknown