Hydrops fetalis
Gene: FLT4
Non-immune fetal hydrops is a rare prenatal manifestation of Lymphedema, hereditary, IA (Milroy diease, OMIM:153100), but in general Milroy disease is not associated with more widespread lymphatic abnormalities.
A Ghalamkarpour et al (PMID:16965327) reported V878M substitution in a 22-week old fetus who was found to have fetal hydrops with bilateral leg edema, pleural effusions, hydrothorax, and pulmonary hypoplasia.
Daniel-Spiegel et al (PMID:16231305) report a case of primary congenital lymphedema (PCL) presenting as hydrops fetalis.Created: 29 Mar 2022, 12:07 a.m. | Last Modified: 29 Mar 2022, 12:07 a.m.
Panel Version: 0.241
Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Phenotypes
Lymphatic malformation 1, MIM# 153100
Publications
Gene: flt4 has been classified as Green List (High Evidence).
Phenotypes for gene: FLT4 were changed from to Lymphatic malformation 1, MIM# 153100
Publications for gene: FLT4 were set to
Mode of inheritance for gene: FLT4 was changed from Unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
gene: FLT4 was added gene: FLT4 was added to Hydrops fetalis_VCGS. Sources: Expert Review Green,Victorian Clinical Genetics Services Mode of inheritance for gene: FLT4 was set to Unknown