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  2. Hypertrophic cardiomyopathy_HCM
  3. KLF10
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Hypertrophic cardiomyopathy_HCM

Gene: KLF10

Red List (low evidence)
KLF10 (Kruppel like factor 10)
EnsemblGeneIds (GRCh38): ENSG00000155090
EnsemblGeneIds (GRCh37): ENSG00000155090
OMIM: 601878, Gene2Phenotype
KLF10 is in 2 panels

1 review

Naomi Baker (Victorian Clinical Genetics Services)

Red List (low evidence)

Curated by ClinGen and rated as limited evidence.

Misssense mutations reported in six unrelated individuals patients (two males/four females), with family history of HCM only reported for one individual (PMID: 22234868). No further reports in the literature.
Sources: Literature
Created: 29 Jul 2020, 12:06 a.m.

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Phenotypes
HCM

Publications

Created: 29 Jul 2020, 12:06 a.m.

Panel version: 0.89

Details

Mode of Inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Sources
  • Expert Review Red
Phenotypes
  • HCM
OMIM
601878
Clinvar variants
Variants in KLF10
Penetrance
None
Publications
Panels with this gene

History Filter Activity

29 Jul 2020, Gel status: 1

Entity classified by Genomics England curator

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Gene: klf10 has been classified as Red List (Low Evidence).

29 Jul 2020, Gel status: 1

Entity classified by Genomics England curator

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Gene: klf10 has been classified as Red List (Low Evidence).

29 Jul 2020, Gel status: 0

Created, Added New Source, Set mode of inheritance, Set publications, Set Phenotypes

Naomi Baker (Victorian Clinical Genetics Services)

gene: KLF10 was added gene: KLF10 was added to Hypertrophic cardiomyopathy_HCM. Sources: Literature Mode of inheritance for gene: KLF10 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted Publications for gene: KLF10 were set to PMID: 22234868 Phenotypes for gene: KLF10 were set to HCM Review for gene: KLF10 was set to RED