Heterotaxy
Gene: TTC25
At least 7 families reported now.Created: 14 Jul 2022, 8:39 a.m. | Last Modified: 14 Jul 2022, 8:39 a.m.
Panel Version: 1.18
2 families reported with PCD. Mouse model showed immotile nodal cilia.
Gene ncodes a component of the outer dynein arm required to develop the main mechanical force to generate ciliary beats. (Gene is non coding in gnomad v2 and coding in v3)Created: 6 May 2020, 8:34 a.m. | Last Modified: 6 May 2020, 8:34 a.m.
Panel Version: 0.21
Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal
Phenotypes
Ciliary dyskinesia, primary, 35 (MIM#617092)
Publications
Tag new gene name tag was added to gene: TTC25.
Publications for gene: TTC25 were set to 27486780
Gene: ttc25 has been classified as Green List (High Evidence).
Gene: ttc25 has been classified as Amber List (Moderate Evidence).
Phenotypes for gene: TTC25 were changed from to Ciliary dyskinesia, primary, 35 (MIM#617092)
Publications for gene: TTC25 were set to
Mode of inheritance for gene: TTC25 was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal
Gene: ttc25 has been classified as Amber List (Moderate Evidence).
gene: TTC25 was added gene: TTC25 was added to Heterotaxy_VCGS. Sources: Expert Review Green,Victorian Clinical Genetics Services Mode of inheritance for gene: TTC25 was set to Unknown